Investigating sleep problems in individuals with Down syndrome and Alzheimer's disease
Sleep abnormalities in Down Syndrome-related Alzheimer's disease
This study is looking at how sleep problems might be connected to Alzheimer's disease in people with Down syndrome, focusing on certain genes that could be causing these issues, and it aims to help us understand how these genes affect sleep and thinking skills.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado NIH-funded |
| Lab location | 1 site (Boulder, UNITED STATES) |
| Project ID | NIH-11125901 on NIH RePORTER |
What this research studies
This research explores the connection between sleep disturbances and Alzheimer's disease in individuals with Down syndrome. It focuses on understanding how specific genes, particularly those related to chromosome 21, contribute to these sleep issues and cognitive decline. By examining the roles of Amyloid Precursor Protein (APP) and Regulator of Calcineurin1 (RCAN1), the study aims to uncover the biological mechanisms that link Down syndrome with Alzheimer's-related sleep dysfunction. The research will involve genetic manipulation techniques to assess the impact of these genes on sleep and cognitive functions in a Down syndrome model.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with Down syndrome who are experiencing sleep disturbances or are at risk for Alzheimer's disease.
Not a fit: Patients without Down syndrome or those not experiencing sleep issues related to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of sleep disorders in patients with Down syndrome and Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding the genetic links between Down syndrome and Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Boulder, UNITED STATES
- University of Colorado — Boulder, United States (Active)
Researchers
- Principal investigator: Hoeffer, Charles a — University of Colorado
- Study coordinator: Hoeffer, Charles a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.