Investigating sleep patterns in neurodegenerative dementias
Official title: Wake-sleep Circuitry in Neurodegenerative Dementias
Funded at Beth Israel Deaconess Medical Center · NIH-10988303 · Data updated 2026-11-12
This study is looking at how diseases like Alzheimer's and Parkinson's change sleep patterns in older adults, hoping to find early signs of these conditions by comparing sleep habits in people with different types of dementia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | December 1, 2023 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $777,303 |
| NIH project number | 5R01AG082016-02 |
| Project ID | NIH-10988303 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing sleep disturbances or those diagnosed with Alzheimer's or related dementias.
✕Less likely to help
Patients with sleep disorders not related to neurodegenerative conditions may not benefit from this research.
What this research studies
This research explores how neurodegenerative diseases like Alzheimer's and Parkinson's affect sleep and circadian rhythms in older adults. By analyzing data from individuals who have undergone actigraphy, the study aims to identify specific sleep disturbances that may serve as early indicators of these conditions. The researchers will compare sleep behaviors in patients with different types of dementia to understand how these disorders uniquely impact sleep. This could lead to new ways to detect neurodegeneration before clinical symptoms appear.
Why it matters
Potential benefit: If successful, this research could provide early biomarkers for neurodegenerative diseases, allowing for earlier intervention and management.
How similar studies have gone: Previous research has shown promising results in using sleep patterns as indicators for neurodegenerative diseases, suggesting this approach has potential.
Where this research is happening
-
Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Saper, Clifford B — Beth Israel Deaconess Medical Center
- Study coordinator: Saper, Clifford B
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.