Investigating sleep issues as early signs of depression in young children

Sleep Disturbances and Circadian Misalignment as Potential Markers of Early Childhood Depression

NIH-funded research Washington University · NIH-10897224

This study is looking at how sleep problems in young children, starting at age three, might be linked to early signs of depression, especially in kids with a family history of the condition, to help find ways to spot and support them earlier.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionWashington University NIH-funded
Lab location1 site (Saint Louis, United States)
Project IDNIH-10897224 on NIH RePORTER

What this research studies

This research explores the connection between sleep disturbances and early signs of depression in children as young as three years old. By examining various sleep patterns and disruptions, the study aims to identify potential markers that could indicate a risk for depression. The research will involve collecting data through sleep diaries, actigraphy, and polysomnography from a cohort of mother-infant pairs, focusing on those with a family history of depression. The goal is to enhance early diagnosis and intervention strategies for childhood depression.

Who could benefit from this research

Good fit: Ideal candidates for this research include children aged 3 years and older who may exhibit sleep disturbances and have a familial risk for depression.

Not a fit: Patients who do not have sleep disturbances or a family history of depression may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to earlier identification and intervention for depression in young children, improving their long-term mental health outcomes.

How similar studies have performed: Previous research has shown that sleep disturbances can be significant indicators of depression in older populations, suggesting potential for similar findings in younger children.

Where this research is happening

Saint Louis, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.