Investigating sleep brain activity related to Alzheimer's disease
Official title: Characterizing sleep brain dynamics associated with Alzheimer's disease pathology and progression in humans using EEG source localization and PET
Funded at Stanford University · NIH-11076836 · Data updated 2026-11-12
This study is looking at how your brain works while you sleep and how that might relate to the progression of Alzheimer's disease, with the hope of finding ways to catch the disease early and slow it down.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | December 15, 2022 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $1,503,957 |
| NIH project number | 5R01AG080678-03 |
| Project ID | NIH-11076836 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals at various stages of Alzheimer's disease, from preclinical to mild cognitive impairment and mild dementia.
✕Less likely to help
Patients with advanced Alzheimer's disease or those without any cognitive impairment may not benefit from this research.
What this research studies
This research focuses on understanding how brain activity during sleep is connected to the progression of Alzheimer's disease (AD). By using advanced EEG techniques alongside PET and MRI imaging, the study aims to identify specific brain patterns that correlate with the accumulation of harmful proteins associated with AD. This approach could help in early detection of the disease and in developing interventions that may slow its progression. Participants will undergo sleep monitoring to gather detailed data on their brain dynamics.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection of Alzheimer's disease and new treatment strategies that utilize sleep-related biomarkers.
How similar studies have gone: Previous research has shown promising results in linking sleep dynamics to Alzheimer's pathology, but this study aims to provide a more detailed analysis that has not been extensively explored.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Purdon, Patrick L. — Stanford University
- Study coordinator: Purdon, Patrick L.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.