Investigating sleep behavior disorders and their biomarkers
NAPS2 Polysomnogram Core
['FUNDING_OTHER'] · WASHINGTON UNIVERSITY · NIH-10866385
This study is looking at people with REM sleep behavior disorder (RBD) to find out more about their sleep patterns, which could help doctors understand and treat related conditions better in the future.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-10866385 on ClinicalTrials.gov |
What this research studies
This research focuses on rapid eye movement (REM) sleep behavior disorder (RBD), which involves abnormal behaviors during dreaming. The study aims to collect and analyze polysomnography (PSG) data from over 300 participants with RBD and matched control participants to identify neurophysiological signals that could serve as biomarkers for synucleinopathy-related conditions. By conducting this research across multiple centers, the project seeks to establish reliable RSWA values that can predict the progression of RBD and related disorders. This could ultimately aid in the development of neuroprotective clinical trials for affected individuals.
Who could benefit from this research
Good fit: Ideal candidates include individuals diagnosed with rapid eye movement sleep behavior disorder.
Not a fit: Patients without REM sleep behavior disorder or those with unrelated sleep disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and better management of neurodegenerative diseases associated with RBD.
How similar studies have performed: Previous research has shown promise in using neurophysiological markers to predict neurodegenerative diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ST. LOUIS, ERIK KENT — WASHINGTON UNIVERSITY
- Study coordinator: ST. LOUIS, ERIK KENT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: behavior disorder diagnosis