Investigating sleep and temperature disturbances as risk factors for Alzheimer's in individuals with Down syndrome.

Who could benefit from this research

What this research studies

This research focuses on understanding how sleep and body temperature disturbances may contribute to the risk of developing Alzheimer's Disease in individuals with Down syndrome. By examining a cohort of individuals with Down syndrome, the study aims to identify specific modifiable factors, such as obstructive sleep apnea and circadian rhythm disruptions, that could influence the onset of Alzheimer's. The research will utilize clinical assessments and biomarker analysis to track changes over time, providing insights into how these factors may be addressed to improve health outcomes.

Why it matters

Where this research is happening

• New York University School of Medicine
  New York, United States Active

Researchers

• Principal investigator: Blessing, Esther Marian — New York University School of Medicine
• Study coordinator: Blessing, Esther Marian

Related research

Other NIH-funded projects on the same topics.

• How sleep and body temperature affect Alzheimer's risk in adults with Down syndrome

  Researchers will follow adults with Down syndrome over several years to learn whether sleep problems and lower body temperature are linked to earlier Alzheimer's changes.

  NIH research New York University School of Medicine · New York, United States · NIH-11508145

• Sleep and body temperature changes linked to Alzheimer’s risk in adults with Down syndrome

  This project looks at whether sleep problems and lower body temperature in adults with Down syndrome are linked to higher chances of developing Alzheimer’s disease.

  NIH research New York University School of Medicine · New York, United States · NIH-11456945

• P-CARRS-BRAIN: Predicting Alzheimer’s risk in South Asians in India using genetic, behavior, and vascular data

  Aims to predict Alzheimer’s disease risk in middle-aged South Asians by combining genetic, lifestyle, and vascular information to catch early changes before dementia develops.

  NIH research Emory University · Atlanta, United States · NIH-11604418

• P-CARRS-BRAIN: Predicting Alzheimer’s risk in South Asians in India using genetics, behavior, and vascular data

  Aimed at people 21 and older, this project looks at how biology, behavior, and blood vessel health together may signal the early risk of Alzheimer’s disease and related dementias in South Asians.

  NIH research Emory University · Atlanta, United States · NIH-11604417

• Sex-specific blood biomarkers predict dementia risk in older adults

  This NIH project tests how blood biomarkers and sex differences predict future dementia in older people, with the goal of personalized prognosis and prevention.

  NIH research Hennepin Healthcare Research Institute · Minneapolis, United States · NIH-11588438

• DS-ARC: Smartphone-based cognitive check for people with Down syndrome at risk for Alzheimer’s

  A smartphone-based cognitive test is being developed and tested for people with Down syndrome who may develop Alzheimer’s disease, to track changes quietly in daily life.

  NIH research Washington University · Saint Louis, United States · NIH-11588336

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.