Investigating sleep and temperature disturbances as risk factors for Alzheimer's in individuals with Down syndrome.
Sleep and Temperature Disturbance as risk factors for Alzheimer's Disease in Down Syndrome: a Longitudinal Study
This study is looking at how problems with sleep and body temperature might increase the risk of Alzheimer's Disease in people with Down syndrome, and it aims to find ways to improve their health by focusing on things like sleep apnea and sleep patterns.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10591135 on NIH RePORTER |
What this research studies
This research focuses on understanding how sleep and body temperature disturbances may contribute to the risk of developing Alzheimer's Disease in individuals with Down syndrome. By examining a cohort of individuals with Down syndrome, the study aims to identify specific modifiable factors, such as obstructive sleep apnea and circadian rhythm disruptions, that could influence the onset of Alzheimer's. The research will utilize clinical assessments and biomarker analysis to track changes over time, providing insights into how these factors may be addressed to improve health outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older with Down syndrome who are at risk for Alzheimer's Disease.
Not a fit: Patients without Down syndrome or those who are not at risk for Alzheimer's Disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to targeted interventions that reduce the risk of Alzheimer's Disease in individuals with Down syndrome.
How similar studies have performed: Previous research has shown promising results in identifying modifiable risk factors for Alzheimer's Disease, suggesting that this approach may yield valuable insights.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Blessing, Esther Marian — New York University School of Medicine
- Study coordinator: Blessing, Esther Marian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.