Investigating sleep and brain cell changes in a mouse model of Alzheimer's disease
Alteration of sleep and cortical parvalbumin interneurons in mouse model of Alzheimers disease
This study is looking at how sleep problems in mice with Alzheimer's disease are connected to certain brain cells, hoping to find ways to help improve sleep and memory for people at risk of Alzheimer's.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11012277 on NIH RePORTER |
What this research studies
This research explores the relationship between sleep disturbances and the activity of specific brain cells called parvalbumin interneurons in a mouse model of Alzheimer's disease (AD). The study aims to understand how these changes in brain cell function may contribute to sleep problems and cognitive decline associated with AD. By using established mouse models, the researchers will examine brain regions critical for sleep and memory, with the goal of identifying early interventions that could prevent or slow down the progression of Alzheimer's. The findings could lead to new strategies for addressing sleep issues and cognitive impairment in individuals at risk for AD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for Alzheimer's disease, particularly those experiencing early signs of cognitive impairment or sleep disturbances.
Not a fit: Patients who are not at risk for Alzheimer's disease or do not exhibit any cognitive or sleep-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new interventions that help prevent sleep disturbances and cognitive decline in individuals at risk for Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of sleep and neuronal activity in Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Harvard Medical School — Boston, United States (Active)
Researchers
- Principal investigator: Katsuki, Fumi — Harvard Medical School
- Study coordinator: Katsuki, Fumi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.