Investigating skin blistering caused by toxic substances
Dermal-Epidermal Junction Disruptors: Toxicodynamic Mechanisms
['FUNDING_OTHER'] · ST. JOHN'S UNIVERSITY · NIH-11037473
This study is looking at how certain harmful substances can cause skin blisters and aims to find ways to protect the skin from damage, which could help people who suffer from skin injuries due to chemicals.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ST. JOHN'S UNIVERSITY (nih funded) |
| Locations | 1 site (QUEENS, UNITED STATES) |
| Trial ID | NIH-11037473 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how certain toxic substances, known as dermal-epidermal junction (DEJ) disruptors, cause the skin to blister. The study will explore the roles of various immune mediators and skin proteins in this process, using mouse models to simulate the effects of these disruptors. By applying different treatments before exposure to these toxins, researchers aim to uncover the mechanisms behind skin damage and potentially identify ways to mitigate these effects. The findings could lead to better understanding and treatment options for skin injuries caused by chemical exposure.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals with a history of skin reactions to chemical exposures or those at risk of such injuries.
Not a fit: Patients with skin conditions unrelated to chemical exposure or those who do not experience blistering may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for skin injuries caused by toxic substances, enhancing patient recovery and care.
How similar studies have performed: While the specific mechanisms of DEJ disruption are not well-studied, similar research on skin injury and healing has shown promising results in understanding and treating skin damage.
Where this research is happening
QUEENS, UNITED STATES
- ST. JOHN'S UNIVERSITY — QUEENS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BILLACK, BLASE CHRISTOPHER — ST. JOHN'S UNIVERSITY
- Study coordinator: BILLACK, BLASE CHRISTOPHER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Anti-Cancer Agents