Investigating skin blistering caused by toxic substances
Official title: Dermal-Epidermal Junction Disruptors: Toxicodynamic Mechanisms
Funded at St. John's University · NIH-11037473 · Data updated 2026-11-12
This study is looking at how certain harmful substances can cause skin blisters and aims to find ways to protect the skin from damage, which could help people who suffer from skin injuries due to chemicals.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. John's University NIH-funded |
| Lab location | 1 site (Queens, United States) |
| Project start | July 15, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $54,339 |
| NIH project number | 3R16GM149512-02S1 |
| Project ID | NIH-11037473 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would include individuals with a history of skin reactions to chemical exposures or those at risk of such injuries.
✕Less likely to help
Patients with skin conditions unrelated to chemical exposure or those who do not experience blistering may not benefit from this research.
What this research studies
This research focuses on understanding how certain toxic substances, known as dermal-epidermal junction (DEJ) disruptors, cause the skin to blister. The study will explore the roles of various immune mediators and skin proteins in this process, using mouse models to simulate the effects of these disruptors. By applying different treatments before exposure to these toxins, researchers aim to uncover the mechanisms behind skin damage and potentially identify ways to mitigate these effects. The findings could lead to better understanding and treatment options for skin injuries caused by chemical exposure.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for skin injuries caused by toxic substances, enhancing patient recovery and care.
How similar studies have gone: While the specific mechanisms of DEJ disruption are not well-studied, similar research on skin injury and healing has shown promising results in understanding and treating skin damage.
Where this research is happening
-
St. John's University
Queens, United States Active
Researchers
- Principal investigator: Billack, Blase Christopher — St. John's University
- Study coordinator: Billack, Blase Christopher
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.