Investigating sinus disease in young children with cystic fibrosis
Official title: Sinus Disease in Young Children with Cystic Fibrosis
Funded at University of California Los Angeles · NIH-10945299 · Data updated 2026-11-12
This study is looking at how chronic rhinosinusitis affects young children with cystic fibrosis and whether a new treatment can help improve their sinus health and sense of smell.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | July 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $687,448 |
| NIH project number | 1R01HL174913-01 |
| Project ID | NIH-10945299 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are young children diagnosed with cystic fibrosis who are experiencing chronic rhinosinusitis.
✕Less likely to help
Patients who do not have cystic fibrosis or who are older than the targeted age group may not benefit from this research.
What this research studies
This research focuses on understanding how chronic rhinosinusitis (CRS) affects young children with cystic fibrosis (CF) and how their olfactory function is impacted. The study aims to evaluate the effects of highly effective CF transmembrane conductance regulator modulator therapy (HEMT) on these conditions. By observing children before and after starting HEMT, researchers hope to determine if early treatment can lead to significant improvements in sinus health and smell function. This research is particularly important as CRS can severely affect the quality of life and overall health in these young patients.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for sinus disease and olfactory dysfunction in young children with cystic fibrosis.
How similar studies have gone: Previous research has shown that adults with cystic fibrosis experience improvements in sinus disease after starting HEMT, suggesting potential for similar benefits in younger patients.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Beswick, Daniel M — University of California Los Angeles
- Study coordinator: Beswick, Daniel M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.