Investigating shared genetic factors in pediatric cancers
Official title: Genetic pleiotropy across pediatric cancers, and cancer-related outcomes
Funded at St. Jude Children's Research Hospital · NIH-11090561 · Data updated 2026-11-12
This study is looking at the genetic links between different types of childhood cancers to see how these shared genes might affect how kids respond to treatment, with the goal of finding better ways to help them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project start | May 16, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $679,091 |
| NIH project number | 5R01CA283333-02 |
| Project ID | NIH-11090561 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include children diagnosed with any type of cancer, particularly those under the age of 11.
✕Less likely to help
Patients with adult-onset cancers or those not diagnosed with cancer may not receive any benefit from this research.
What this research studies
This research aims to explore the genetic connections among various types of pediatric cancers, focusing on how these shared genetic factors may influence cancer outcomes. By analyzing a large dataset of over 43,000 pediatric cancer cases, the study will utilize advanced genomic techniques to identify common genetic markers across more than 25 cancer subtypes. This comprehensive approach seeks to enhance our understanding of cancer predisposition and improve treatment strategies for affected children.
Why it matters
Potential benefit: If successful, this research could lead to improved risk assessment and targeted therapies for children diagnosed with cancer.
How similar studies have gone: Previous research has shown success in identifying genetic factors in individual cancer types, but this study represents a novel approach by examining genetic pleiotropy across multiple pediatric cancers.
Where this research is happening
-
St. Jude Children's Research Hospital
Memphis, United States Active
Researchers
- Principal investigator: Wang, Zhaoming — St. Jude Children's Research Hospital
- Study coordinator: Wang, Zhaoming
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.