Investigating sex differences in kidney disease related to diabetes
Sexual dimorphisms and role of the cGAS-STING pathway in diabetic nephropathy
This study is looking at how diabetic kidney disease affects men and women differently by examining a special type of diabetic rat, with the hope of finding new ways to treat this condition for everyone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-11113858 on NIH RePORTER |
What this research studies
This research focuses on understanding how diabetic kidney disease (DKD) affects men and women differently. By studying a specific type of diabetic rat model, researchers aim to uncover the molecular mechanisms behind these differences, particularly the role of inflammatory pathways. The goal is to identify how these pathways contribute to kidney damage in both sexes, which could lead to more personalized treatment options for patients with DKD. The study will involve detailed comparisons of kidney function and structure between male and female rats to better understand the progression of the disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with diabetic kidney disease, particularly those who may experience different symptoms or disease progression based on their sex.
Not a fit: Patients without diabetes or those who do not have kidney disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and tailored treatments for diabetic kidney disease based on sex differences.
How similar studies have performed: Previous research has shown that understanding sex differences in disease mechanisms can lead to significant advancements in treatment, suggesting this approach has potential for success.
Where this research is happening
Tampa, United States
- University of South Florida — Tampa, United States (Active)
Researchers
- Principal investigator: Staruschenko, Alexander — University of South Florida
- Study coordinator: Staruschenko, Alexander
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.