Investigating sex differences in immune responses and neuroprotection in Multiple Sclerosis
TNFR2 sex differences and EAE
['FUNDING_R01'] · GEORGE WASHINGTON UNIVERSITY · NIH-11074117
This study is looking at how men and women with Multiple Sclerosis respond differently to treatments that help protect the nervous system, focusing on a specific signaling pathway that might help women recover better from inflammation-related damage.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | GEORGE WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (WASHINGTON, UNITED STATES) |
| Trial ID | NIH-11074117 on ClinicalTrials.gov |
What this research studies
This research explores how sex differences affect the immune response and neuroprotection in Multiple Sclerosis (MS). It focuses on the role of TNFR2 signaling in females, which may enhance their ability to repair and protect the central nervous system from inflammation-related damage. The study will involve examining the effects of TNFR2 activation on motor function and neuropathology in experimental models of MS, particularly looking at how these mechanisms differ between males and females. By understanding these differences, the research aims to identify potential therapeutic targets for improving outcomes in MS patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Multiple Sclerosis, particularly those interested in understanding the role of sex differences in their condition.
Not a fit: Patients with other neurological disorders or those not diagnosed with Multiple Sclerosis may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance neuroprotection and repair mechanisms in MS, particularly for male patients who experience more severe disease progression.
How similar studies have performed: Previous research has shown promising results in understanding sex differences in immune responses, suggesting that this approach could yield significant insights and advancements in treatment.
Where this research is happening
WASHINGTON, UNITED STATES
- GEORGE WASHINGTON UNIVERSITY — WASHINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BETHEA, JOHN ROLAND — GEORGE WASHINGTON UNIVERSITY
- Study coordinator: BETHEA, JOHN ROLAND
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: burden of disease