Investigating sex differences in Alzheimer's disease and related dementias
Official title: Diversity Supplement for Jenny Lutshumba
Funded at University of Kentucky · NIH-11062866 · Data updated 2026-11-12
This study is looking at how being male or female might change the way Alzheimer's disease develops and progresses, especially by examining certain biological markers and health factors in older adults, with the hope of finding better ways to prevent and treat the disease for everyone.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $302,626 |
| NIH project number | 3RF1AG084134-01S1 |
| Project ID | NIH-11062866 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include older adults, particularly women, who are cognitively healthy but may be at risk for Alzheimer's disease or related dementias.
✕Less likely to help
Patients who are not older adults or those who do not have a risk of Alzheimer's disease or related dementias may not benefit from this research.
What this research studies
This research focuses on understanding how sex differences affect the development and progression of Alzheimer's disease and vascular contributions to cognitive impairment and dementia. It aims to explore the relationship between sex-based biological factors and the levels of specific biomarkers associated with these conditions in older adults. By analyzing data from a clinical trial, the study seeks to uncover how systemic inflammation and cardiovascular risk factors may differ between males and females, potentially influencing dementia outcomes. The findings could lead to more tailored prevention and treatment strategies for Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for Alzheimer's disease, particularly for women who are disproportionately affected.
How similar studies have gone: Previous research has indicated that sex differences play a significant role in the pathology of Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Kentucky
Lexington, United States Active
Researchers
- Principal investigator: Stowe, Ann Marie — University of Kentucky
- Study coordinator: Stowe, Ann Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.