Investigating serotonin receptors to develop new treatments for opioid use disorders
Delineating the role of serotonin 5-HT2 receptors in opioid use disorders: Development of novel 5-HT2 modulators with translational studies in rodents and primates
['FUNDING_R01'] · NORTHEASTERN UNIVERSITY · NIH-10410391
This study is looking at how certain brain receptors can help create new medications to reduce cravings and prevent relapse for people struggling with opioid addiction, using tests on animals to find safe and effective treatments.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHEASTERN UNIVERSITY (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10410391 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how serotonin receptors, specifically the 5-HT2A and 5-HT2C subtypes, can be targeted to create new medications for opioid use disorder (OUD). The approach involves developing specific agonists that activate the 5-HT2C receptor while avoiding the negative effects associated with the other receptor subtypes. By conducting experiments in both rodent and primate models, the research aims to identify safe and effective pharmacological treatments that can reduce opioid cravings and prevent relapse. This could lead to innovative therapies that address the urgent public health crisis of opioid addiction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with opioid use disorder who are seeking alternative treatment options.
Not a fit: Patients who are not struggling with opioid use disorder or those who have not responded to previous treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new, non-addictive treatment options for individuals struggling with opioid use disorders.
How similar studies have performed: Previous research has shown promise in targeting serotonin receptors for addiction treatment, indicating potential for success in this novel approach.
Where this research is happening
BOSTON, UNITED STATES
- NORTHEASTERN UNIVERSITY — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BOOTH, RAYMOND G. — NORTHEASTERN UNIVERSITY
- Study coordinator: BOOTH, RAYMOND G.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.