Investigating RNA sequences and their modifications to improve understanding of diseases.
Exhaustive de novo sequencing of every RNA in a sample by a layer-by-layer mass spectrometry ladder intensity approach.
This study is looking at RNA, which plays a big role in diseases like breast cancer, using a new method to get a clearer picture of its details, so we can better understand how these diseases work and find new ways to treat them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Directseq Biosciences, INC. NIH-funded |
| Lab location | 1 site (Woodcliff Lake, United States) |
| Project ID | NIH-11003488 on NIH RePORTER |
What this research studies
This research focuses on the comprehensive analysis of RNA sequences and their modifications, which are crucial for understanding various diseases, including breast cancer. The approach utilizes a novel layer-by-layer mass spectrometry technique to capture every RNA molecule in a sample, addressing the limitations of current sequencing technologies that often miss critical information. By directly analyzing RNA without converting it to cDNA, the study aims to provide a more accurate representation of RNA content and modifications, which could lead to better insights into disease mechanisms and potential treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with breast cancer, skin cancer, lung cancer, or other diseases linked to RNA modification defects.
Not a fit: Patients without any RNA-related diseases or those not affected by the specific conditions being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic and therapeutic strategies for patients with RNA-related diseases.
How similar studies have performed: While RNA sequencing has been explored in various contexts, this specific approach using layer-by-layer mass spectrometry is innovative and has not been widely tested in previous studies.
Where this research is happening
Woodcliff Lake, United States
- Directseq Biosciences, INC. — Woodcliff Lake, United States (Active)
Researchers
- Principal investigator: Zhang, Shenglong — Directseq Biosciences, INC.
- Study coordinator: Zhang, Shenglong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.