Investigating RNA modifications in mouse eggs
Official title: A-to-I RNA modifications in mouse oocytes
Funded at Old Dominion University · NIH-11178183 · Data updated 2026-11-12
This study is looking at how a process called RNA editing, especially involving an enzyme named ADAR1, affects the quality of eggs in mice, which could help us understand fertility and birth defects in both young and older mice.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Old Dominion University NIH-funded |
| Lab location | 1 site (Norfolk, United States) |
| Project start | August 26, 2019 |
| Project end | February 28, 2026 |
| Funding year | 2024 |
| Award (this year) | $87,651 |
| NIH project number | 6R00HD099269-06 |
| Project ID | NIH-11178183 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women experiencing difficulty conceiving or those interested in understanding the biological factors affecting fertility.
✕Less likely to help
Patients who are not affected by infertility or birth defects may not receive direct benefits from this research.
What this research studies
This research explores how RNA editing affects the quality of eggs in mice, particularly focusing on a specific enzyme called ADAR1. By studying both young and older mice, the research aims to understand how changes in RNA stability and editing might influence fertility and the potential for birth defects. The project includes a combination of mentorship and training for the researcher, ensuring a thorough approach to the investigation. The findings could provide insights into the biological mechanisms behind infertility and developmental issues.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for addressing infertility and reducing the risk of birth defects.
How similar studies have gone: While the specific role of ADAR1 in fertility has not been extensively studied, related research on RNA modifications has shown promising results in understanding reproductive health.
Where this research is happening
-
Old Dominion University
Norfolk, United States Active
Researchers
- Principal investigator: Brachova, Pavla — Old Dominion University
- Study coordinator: Brachova, Pavla
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.