Investigating RNA modifications in Alzheimer's Disease
Official title: Functional epitranscriptomic profiling of m6A RNA modifications in Alzheimer's Disease
Funded at Boston University Medical Campus · NIH-10998129 · Data updated 2026-11-12
This study is looking at how certain changes in RNA, called m6A modifications, might be linked to Alzheimer's Disease by examining brain samples from people and mice, with the hope of finding new ways to understand and treat the condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 19, 2024 |
| Project end | November 7, 2026 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31AG090051-01 |
| Project ID | NIH-10998129 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's Disease or those at risk for developing it.
✕Less likely to help
Patients with other forms of dementia or neurodegenerative diseases unrelated to Alzheimer's may not benefit from this research.
What this research studies
This research focuses on understanding how specific RNA modifications, known as m6A, are altered in Alzheimer's Disease. By examining brain samples from both humans and mouse models, the study aims to identify changes in m6A-modified RNA that may contribute to the disease's progression. The researchers will utilize advanced sequencing techniques to analyze these modifications and their relationship with amyloid beta and tau proteins, which are key players in Alzheimer's pathology. This work could provide insights into the molecular mechanisms underlying Alzheimer's and potentially lead to new therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for diagnosing or treating Alzheimer's Disease by targeting RNA modifications.
How similar studies have gone: Previous research has shown promising results in understanding RNA modifications in other neurodegenerative diseases, suggesting that this approach may yield valuable insights in Alzheimer's as well.
Where this research is happening
-
Boston University Medical Campus
Boston, United States Active
Researchers
- Principal investigator: Libera, Jenna Lynn — Boston University Medical Campus
- Study coordinator: Libera, Jenna Lynn
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.