Investigating RNA modifications and their impact on COVID-19 complications
Official title: CASP-11-dependent RNA modifications and their Role in Multi-Organ Pathologies
Funded at Ohio State University · NIH-11072982 · Data updated 2026-11-12
This study is looking at how changes in RNA can affect the SARS-CoV-2 virus and cause problems in different organs, with the goal of finding new ways to treat COVID-19 and help patients feel better.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | April 10, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $429,216 |
| NIH project number | 5P01AI175399-02 |
| Project ID | NIH-11072982 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have been diagnosed with COVID-19, especially those experiencing severe symptoms or complications.
✕Less likely to help
Patients who have not been infected with SARS-CoV-2 or those with mild cases that do not require advanced therapeutic interventions may not benefit from this research.
What this research studies
This research focuses on understanding how RNA modifications affect the replication of the SARS-CoV-2 virus and contribute to complications in multiple organs. By studying the role of specific enzymes involved in RNA modification, the research aims to uncover new therapeutic strategies to combat COVID-19. The approach includes both laboratory experiments and potential clinical applications, targeting the inhibition of RNA modifying enzymes and CASP11 to improve antiviral therapies. Patients may benefit from insights that could lead to more effective treatments for COVID-19 and its associated health issues.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antiviral therapies that significantly improve outcomes for patients with COVID-19.
How similar studies have gone: Previous research has shown promising results in targeting RNA modifications and related pathways in viral infections, indicating potential for success in this novel approach.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Li, Jianrong — Ohio State University
- Study coordinator: Li, Jianrong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.