Investigating RNA-binding proteins in malaria-causing parasites
Official title: RNA-Binding Proteins and RNA-Dependent Proteins - An Emerging Role for RNAs in Plasmodium Biology
Funded at University of California Riverside · NIH-11163028 · Data updated 2026-11-12
This study is looking at specific proteins in the malaria parasite that help it grow and survive, with the hope of finding new ways to create better treatments for people with malaria.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Riverside NIH-funded |
| Lab location | 1 site (Riverside, United States) |
| Project start | February 1, 2025 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $215,751 |
| NIH project number | 1R21AI191405-01 |
| Project ID | NIH-11163028 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living in malaria-endemic regions who are at risk of contracting malaria.
✕Less likely to help
Patients who do not live in malaria-endemic areas or those who are not at risk of malaria infection may not benefit from this research.
What this research studies
This research focuses on understanding the role of RNA-binding proteins (RBPs) and RNA-dependent proteins (RDPs) in the development of the malaria parasite Plasmodium falciparum. By using advanced techniques such as mass spectrometry and computational analysis, the researchers aim to identify and characterize these proteins, which are crucial for the parasite's life cycle. The ultimate goal is to discover new pathways that can be targeted for developing effective anti-malarial treatments, potentially leading to better outcomes for patients suffering from malaria.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel anti-malarial therapies that are more effective in treating malaria.
How similar studies have gone: Previous research has shown promise in targeting RNA-related pathways in other parasitic infections, suggesting potential for success in this novel approach.
Where this research is happening
-
University of California Riverside
Riverside, United States Active
Researchers
- Principal investigator: Le Roch, Karine Gaelle — University of California Riverside
- Study coordinator: Le Roch, Karine Gaelle
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.