Investigating risk factors for Alzheimer's Disease in South Asians
Official title: P-CARRS-BRAIN: Multi-domain (genetic, socio-behavioral, vascular) risk factors and prediction of Alzheimer’s Disease continuum in South Asians in India
Funded at Emory University · NIH-10992037 · Data updated 2026-11-12
This study is looking at the early signs and risk factors for Alzheimer's and related dementias in South Asians, who are more likely to develop these conditions, to help find ways to spot them early and support those at risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | September 15, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $4,282,638 |
| NIH project number | 1R01AG089759-01 |
| Project ID | NIH-10992037 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are South Asians, particularly those in middle age, who may be at risk for Alzheimer's Disease or related dementias.
✕Less likely to help
Patients who are not of South Asian descent or those who do not have risk factors for Alzheimer's Disease may not benefit from this research.
What this research studies
This research focuses on understanding the early signs and risk factors of Alzheimer's Disease and related dementias (AD/ADRD) in South Asians, a group at higher risk for these conditions. By analyzing a large cohort with extensive health data, the study aims to identify genetic, socio-behavioral, and vascular factors that contribute to the development of AD/ADRD. The researchers will use advanced machine learning techniques to create predictive models that can help in early detection and intervention for individuals at risk. This approach seeks to fill the gaps in knowledge about preclinical stages of Alzheimer's, particularly in middle-aged individuals.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and better prevention strategies for Alzheimer's Disease in high-risk populations.
How similar studies have gone: Other research has shown promise in using multimodal data and machine learning for early detection of Alzheimer's, indicating that this approach could be effective.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Narayan, Kabayam M Venkat — Emory University
- Study coordinator: Narayan, Kabayam M Venkat
Related research
Other NIH-funded projects on the same topics.
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P-CARRS-BRAIN: Predicting Alzheimer’s risk in South Asians in India using genetic, behavior, and vascular data
Aims to predict Alzheimer’s disease risk in middle-aged South Asians by combining genetic, lifestyle, and vascular information to catch early changes before dementia develops.
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P-CARRS-BRAIN: Predicting Alzheimer’s risk in South Asians in India using genetics, behavior, and vascular data
Aimed at people 21 and older, this project looks at how biology, behavior, and blood vessel health together may signal the early risk of Alzheimer’s disease and related dementias in South Asians.
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Sex-specific blood biomarkers predict dementia risk in older adults
This NIH project tests how blood biomarkers and sex differences predict future dementia in older people, with the goal of personalized prognosis and prevention.
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How sleep and body temperature affect Alzheimer's risk in adults with Down syndrome
Researchers will follow adults with Down syndrome over several years to learn whether sleep problems and lower body temperature are linked to earlier Alzheimer's changes.
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Sleep and body temperature changes linked to Alzheimer’s risk in adults with Down syndrome
This project looks at whether sleep problems and lower body temperature in adults with Down syndrome are linked to higher chances of developing Alzheimer’s disease.
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Sex-specific blood biomarkers to predict Alzheimer's and related dementias
This project aims to use blood biomarkers to predict risk of Alzheimer's-related conditions in older adults, with attention to how sex differences may change risk.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.