Investigating risk factors for Alzheimer's disease and related dementias

Population Based Research for Alzheimer's Innovation (POP BRAIN)

NIH-funded research University of California, San Francisco · NIH-10893603

This study, led by Dr. Kristine Yaffe, is looking at how things like exercise, sleep, and heart health can affect the risk of developing Alzheimer's and similar conditions, with the goal of finding ways to help people stay sharp as they age.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionUniversity of California, San Francisco NIH-funded
Lab location1 site (San Francisco, United States)
Project IDNIH-10893603 on NIH RePORTER

What this research studies

This research focuses on understanding the risk factors associated with Alzheimer's disease and related dementias, particularly those that can be modified. The team, led by Dr. Kristine Yaffe, employs a multidisciplinary approach to study various influences such as physical activity, sleep quality, and cardiovascular health. By analyzing population data, the research aims to identify effective strategies for preventing cognitive decline and improving health outcomes for individuals at risk. The project also emphasizes training the next generation of researchers in this critical field.

Who could benefit from this research

Good fit: Ideal candidates for this research include individuals at risk for Alzheimer's disease, particularly those with modifiable risk factors.

Not a fit: Patients with advanced Alzheimer's disease or those who do not have any identifiable risk factors may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved prevention strategies and interventions for Alzheimer's disease and related dementias.

How similar studies have performed: Previous research has shown success in identifying modifiable risk factors for Alzheimer's disease, making this approach both relevant and promising.

Where this research is happening

San Francisco, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Alzheimer disease dementiaAlzheimer syndromeAlzheimer's DiseaseAlzheimer's disease and related dementiaAlzheimer's disease and related disorders
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.