Investigating retinal biochemistry before and after organ transplant
Official title: In vivo 2-photon imaging of retinal biochemistry before and after retinal organoid transplantation
Funded at University of California-Irvine · NIH-11098448 · Data updated 2026-11-12
This study is looking at how new imaging technology can help us see changes in the eye's retina before and after using tiny lab-grown eye tissues, which could lead to better treatments for age-related macular degeneration.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $194,262 |
| NIH project number | 5K08EY034912-03 |
| Project ID | NIH-11098448 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who are experiencing age-related macular degeneration.
✕Less likely to help
Patients with retinal conditions unrelated to age-related macular degeneration may not benefit from this research.
What this research studies
This research focuses on using advanced imaging techniques to observe the biochemical changes in the retina before and after the transplantation of retinal organoids. The principal investigator, Dr. Browne, aims to develop functional imaging tools that can provide insights into eye diseases, particularly age-related macular degeneration. By utilizing in vivo two-photon imaging, the study will enhance our understanding of retinal cellular biology and potentially lead to improved therapies for patients. The research involves collaboration with experienced mentors and aims to train the investigator in advanced imaging and molecular interpretation techniques.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic and therapeutic strategies for patients suffering from age-related macular degeneration.
How similar studies have gone: Previous research using similar imaging techniques has shown promise in understanding retinal diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California-Irvine
Irvine, United States Active
Researchers
- Principal investigator: Browne, Andrew W — University of California-Irvine
- Study coordinator: Browne, Andrew W
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.