Investigating renal denervation for heart failure with preserved ejection fraction
Official title: Renal Denervation in Heart Failure with Preserved Ejection Fraction
Funded at Cedars-Sinai Medical Center · NIH-10890192 · Data updated 2026-11-12
This study is looking at a new way to help people with heart failure that keeps their heart's pumping ability normal, by testing a procedure called renal denervation in pigs to see if it can improve heart and blood vessel function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | May 3, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $789,349 |
| NIH project number | 5R01HL159428-04 |
| Project ID | NIH-10890192 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with heart failure with preserved ejection fraction.
✕Less likely to help
Patients with heart failure with reduced ejection fraction or those not diagnosed with heart failure may not benefit from this research.
What this research studies
This research focuses on heart failure with preserved ejection fraction (HFpEF), a condition that currently lacks effective treatments. The study will explore the effects of renal denervation, a procedure that targets the sympathetic nervous system, on heart and vascular function using a swine model. By inducing HFpEF in pigs and then applying renal denervation, researchers aim to understand how this therapy may help improve heart function and slow disease progression. The approach involves using a specialized catheter system that delivers ultrasound energy to disrupt renal sympathetic nerves.
Why it matters
Potential benefit: If successful, this research could lead to a new treatment option for patients suffering from HFpEF, potentially improving their heart function and quality of life.
How similar studies have gone: While renal denervation has shown promise in other cardiovascular conditions, its application in HFpEF is still being explored and is considered a novel approach.
Where this research is happening
-
Cedars-Sinai Medical Center
Los Angeles, United States Active
Researchers
- Principal investigator: Goodchild, Traci Taylor — Cedars-Sinai Medical Center
- Study coordinator: Goodchild, Traci Taylor
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.