Investigating racial differences in prostate cancer among African American men
Racial Difference in Prostate Cancer
This study is looking into why men of West African descent are more likely to get prostate cancer and why it can be more severe for them, with the hope of finding new ways to improve treatment for African American men facing this disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11073932 on NIH RePORTER |
What this research studies
This research focuses on understanding why men of West African ancestry have a higher risk of prostate cancer and often experience more aggressive forms of the disease. The team aims to explore the interaction between specific transcription factors, Kaiso and ONECUT2, which may drive cancer progression. By using various models, including human tissues and patient-derived xenografts, the researchers will analyze how these factors influence cancer behavior and treatment resistance. The ultimate goal is to identify potential therapeutic targets that could improve outcomes for African American men with prostate cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are African American men diagnosed with prostate cancer.
Not a fit: Patients who do not have prostate cancer or are of non-African ancestry may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments tailored specifically for African American men with prostate cancer.
How similar studies have performed: Previous research has shown promising results in targeting similar transcription factors in cancer treatment, indicating potential for success in this approach.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Freeman, Michael R — Cedars-Sinai Medical Center
- Study coordinator: Freeman, Michael R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.