Investigating racial differences in colorectal cancer through DNA methylation
Official title: Racial Disparities and Colorectal DNA Methylation- Driven Gene Expression
Funded at University of Virginia · NIH-10726172 · Data updated 2026-11-12
This study is looking at how differences in DNA between African Americans and European Americans might explain why African Americans are more likely to develop colorectal cancer, especially on the right side and at a younger age, so we can better understand and address these health disparities.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project start | September 15, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $415,257 |
| NIH project number | 1R21CA283132-01 |
| Project ID | NIH-10726172 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include African American and European American individuals diagnosed with colorectal cancer or at high risk for the disease.
✕Less likely to help
Patients who do not have colorectal cancer or are not at risk for the disease may not benefit from this research.
What this research studies
This research explores how racial disparities affect the development of colorectal cancer (CRC), particularly focusing on the differences in DNA methylation patterns between African Americans and European Americans. By analyzing colorectal biopsies and patient-derived organoids, the study aims to uncover how these epigenetic changes influence gene expression and tumor development. The research seeks to understand why African Americans are more likely to develop right-sided CRC at a younger age compared to their European American counterparts. Through this investigation, the researchers hope to identify the biological mechanisms that contribute to these disparities.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and targeted interventions for colorectal cancer in racially diverse populations.
How similar studies have gone: Previous research has indicated that epigenetic factors play a significant role in cancer disparities, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Virginia
Charlottesville, United States Active
Researchers
- Principal investigator: Li, Li — University of Virginia
- Study coordinator: Li, Li
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.