Investigating proteins involved in neurodegeneration.
Ataxin-2 complex proteins in neurodegeneration.
This study is looking at how certain proteins that bind to RNA might affect brain health, especially in conditions like spinocerebellar ataxias, to find new ways to help people with these neurodegenerative diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-11080374 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of RNA-binding proteins in the ATXN2-complex, which are crucial for RNA metabolism and are linked to neurodegenerative diseases like spinocerebellar ataxias. The team will use advanced techniques to explore how these proteins interact with cellular processes such as autophagy and the unfolded protein response, particularly under stress conditions. By studying these mechanisms, the research aims to uncover new insights into the progression of cerebellar degeneration and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with spinocerebellar ataxias or related neurodegenerative conditions.
Not a fit: Patients with neurodegenerative diseases not related to RNA-binding proteins or spinocerebellar ataxias may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel treatments for neurodegenerative diseases, improving quality of life for affected patients.
How similar studies have performed: Previous research has shown promise in targeting RNA-binding proteins for therapeutic interventions in neurodegenerative diseases, indicating a potential for success in this approach.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Pulst, Stefan M. — University of Utah
- Study coordinator: Pulst, Stefan M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.