Investigating proteins involved in blood coagulation
Molecular Biology, Protein Expression and Structural Biology
This study is looking at important proteins in our blood that help it clot, which could lead to better treatments for people with bleeding disorders.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10768828 on NIH RePORTER |
What this research studies
This research focuses on the molecular biology and structural biology of proteins that play a crucial role in blood coagulation, specifically factors V and VIII. It utilizes advanced techniques such as bacterial and yeast expression systems, as well as mammalian cell lines, to produce and analyze these proteins. The project aims to enhance our understanding of how these proteins function and interact, which could lead to improved treatments for bleeding disorders. Patients may benefit from the development of new therapies based on the insights gained from this research.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with hemophilia or other coagulation disorders.
Not a fit: Patients with coagulation disorders unrelated to factors V and VIII may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new and more effective treatments for patients with bleeding disorders.
How similar studies have performed: Previous research has shown success in understanding coagulation proteins and developing therapies based on similar molecular biology approaches.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Krishnaswamy, Sriram — Children's Hosp of Philadelphia
- Study coordinator: Krishnaswamy, Sriram
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.