Investigating protein synthesis in autism using advanced microscopy techniques
Official title: Localized translational dysregulation in an autism spectrum disorder model using in situ cryo-EM
Funded at University of California Santa Cruz · NIH-10986720 · Data updated 2026-11-12
This study is looking at how problems with protein production in brain cells might affect learning and memory in people with autism, and it hopes to find new ways to help improve these skills.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Santa Cruz NIH-funded |
| Lab location | 1 site (Santa Cruz, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $443,121 |
| NIH project number | 1R21NS137060-01A1 |
| Project ID | NIH-10986720 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with autism spectrum disorder, particularly those with a known genetic basis such as Fragile X syndrome.
✕Less likely to help
Patients with autism spectrum disorder not linked to the FMR1 gene or those with unrelated neurological conditions may not benefit from this research.
What this research studies
This research focuses on understanding how dysregulated protein synthesis affects neuronal plasticity in an autism spectrum disorder (ASD) model. By utilizing innovative in situ cryo-electron microscopy techniques, the study aims to explore the role of specific proteins and their interactions within neuronal cells. The research will examine how the absence of the FMR1 gene product, FMRP, leads to excessive translation and its implications for memory and synaptic function. Patients may benefit from insights gained into the biological mechanisms underlying ASD, potentially leading to new therapeutic approaches.
Why it matters
Potential benefit: If successful, this research could provide critical insights into the biological mechanisms of autism, paving the way for novel treatment strategies.
How similar studies have gone: While the approach of using in situ cryo-electron microscopy is innovative, similar studies have shown promise in understanding protein synthesis in other neurological disorders, suggesting potential for success in this area.
Where this research is happening
-
University of California Santa Cruz
Santa Cruz, United States Active
Researchers
- Principal investigator: Loerch, Sarah — University of California Santa Cruz
- Study coordinator: Loerch, Sarah
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.