Investigating protein synthesis in autism using advanced microscopy techniques
Localized translational dysregulation in an autism spectrum disorder model using in situ cryo-EM
['FUNDING_R21'] · UNIVERSITY OF CALIFORNIA SANTA CRUZ · NIH-10986720
This study is looking at how problems with protein production in brain cells might affect learning and memory in people with autism, and it hopes to find new ways to help improve these skills.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA SANTA CRUZ (nih funded) |
| Locations | 1 site (SANTA CRUZ, UNITED STATES) |
| Trial ID | NIH-10986720 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how dysregulated protein synthesis affects neuronal plasticity in an autism spectrum disorder (ASD) model. By utilizing innovative in situ cryo-electron microscopy techniques, the study aims to explore the role of specific proteins and their interactions within neuronal cells. The research will examine how the absence of the FMR1 gene product, FMRP, leads to excessive translation and its implications for memory and synaptic function. Patients may benefit from insights gained into the biological mechanisms underlying ASD, potentially leading to new therapeutic approaches.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with autism spectrum disorder, particularly those with a known genetic basis such as Fragile X syndrome.
Not a fit: Patients with autism spectrum disorder not linked to the FMR1 gene or those with unrelated neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide critical insights into the biological mechanisms of autism, paving the way for novel treatment strategies.
How similar studies have performed: While the approach of using in situ cryo-electron microscopy is innovative, similar studies have shown promise in understanding protein synthesis in other neurological disorders, suggesting potential for success in this area.
Where this research is happening
SANTA CRUZ, UNITED STATES
- UNIVERSITY OF CALIFORNIA SANTA CRUZ — SANTA CRUZ, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LOERCH, SARAH — UNIVERSITY OF CALIFORNIA SANTA CRUZ
- Study coordinator: LOERCH, SARAH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autistic Disorder