Investigating protein structures using advanced mass spectrometry techniques
Combining Absolute Quantitative Cross-Linking Mass Spectrometry and Molecular Modeling for Probing PROTAC-Mediated Ternary Complex Structures
This study is exploring a new way to look at how proteins are structured and how they change shape, which could help us understand important biological processes better, and it's designed for scientists who work with proteins.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New Jersey Institute of Technology NIH-funded |
| Lab location | 1 site (Newark, United States) |
| Project ID | NIH-10793540 on NIH RePORTER |
What this research studies
This research focuses on developing a new method for analyzing protein structures through absolute quantitative cross-linking mass spectrometry (aqCLMS). By measuring the distance between specific parts of proteins, researchers aim to better understand how proteins change shape and function in different environments. This innovative approach eliminates the need for standard reference materials, making it easier to obtain accurate measurements. The findings could significantly enhance our understanding of protein interactions and dynamics, which are crucial for many biological processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to protein misfolding or dysfunction, such as certain genetic disorders or cancers.
Not a fit: Patients with conditions unrelated to protein structure or function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved drug design and therapeutic strategies by providing deeper insights into protein behavior and interactions.
How similar studies have performed: Previous research has shown promise in using mass spectrometry for protein analysis, indicating that this approach could yield valuable insights.
Where this research is happening
Newark, United States
- New Jersey Institute of Technology — Newark, United States (Active)
Researchers
- Principal investigator: Chen, Hao — New Jersey Institute of Technology
- Study coordinator: Chen, Hao
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.