Investigating protein structures and dynamics in living cells and lab settings.
High-throughput disulfide and FRET scanning to reveal protein conformational ensembles in vitro and in vivo.
This study is all about finding new ways to watch how proteins change shape and work together, which can help us understand important health issues like why some bacteria resist antibiotics and how certain diseases happen when proteins don't fold correctly.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project ID | NIH-11059901 on NIH RePORTER |
What this research studies
This research focuses on developing advanced technologies to study protein conformations both in laboratory settings and within living organisms. It aims to create high-throughput methods for disulfide scanning and single-molecule FRET scanning, which will allow scientists to observe how proteins change shape and interact over time. By understanding these dynamics, the research seeks to address critical biomedical questions, such as how protein structure affects antibiotic resistance in bacteria and the role of protein misfolding in diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by diseases linked to protein misfolding or antibiotic-resistant infections.
Not a fit: Patients with conditions unrelated to protein dynamics or antibiotic resistance may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into protein behavior that may improve treatments for diseases related to protein misfolding and antibiotic resistance.
How similar studies have performed: Other research has shown promise in using advanced techniques to study protein dynamics, suggesting that this approach could yield valuable insights.
Where this research is happening
Stony Brook, United States
- State University New York Stony Brook — Stony Brook, United States (Active)
Researchers
- Principal investigator: Serebryany, Evgeny — State University New York Stony Brook
- Study coordinator: Serebryany, Evgeny
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.