Investigating protein structure in crowded cellular environments
Protein Footprinting Coupled to Mass Spectrometry for the Study of Protein Higher Order Structure in Complex Model Systems
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-10932145
This study is exploring how proteins act in crowded spaces inside cells, using a special technique to see how they interact and change shape, which could help us understand their roles better, especially in a tiny animal called C. elegans.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-10932145 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how proteins behave in crowded cellular environments, which is crucial for their function. It utilizes a technique called fast photochemical oxidation of proteins (FPOP) to study protein interactions and conformational changes in complex model systems, including the use of the C. elegans animal model. By mimicking the in vivo conditions, the research aims to provide insights into protein behavior that are not observable in traditional lab settings. The goal is to develop new methods for studying protein structure and interactions in these challenging environments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to protein misfolding or dysfunction, such as neurodegenerative diseases.
Not a fit: Patients with conditions unrelated to protein interactions or those who do not have a genetic predisposition to protein-related diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of protein functions, which may improve treatments for various diseases linked to protein misfolding or dysfunction.
How similar studies have performed: Other research has shown success with similar approaches in studying protein interactions and structures, indicating a promising avenue for further exploration.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JONES, LISA M — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: JONES, LISA M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.