Investigating protein interactions in lung cancer cells
Official title: Spatial protein-protein interaction networks in situ by multiplexed proximity ligation
Funded at Georgia Institute of Technology · NIH-10918730 · Data updated 2026-11-12
This study is looking at how proteins in lung cancer cells work together, especially in patients with non-small cell lung cancer who have certain genetic changes, to see how they respond to treatments like osimertinib and why some cells become resistant, with the hope of finding better treatment options for you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgia Institute of Technology NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $374,123 |
| NIH project number | 1R33CA291197-01 |
| Project ID | NIH-10918730 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with non-small cell lung cancer who have epidermal growth factor receptor (EGFR) gene mutations.
✕Less likely to help
Patients with lung cancer who do not have EGFR mutations or those with other types of lung cancer may not benefit from this research.
What this research studies
This research focuses on understanding how proteins interact within lung cancer cells, particularly in patients with non-small cell lung cancer (NSCLC) who have specific genetic mutations. By using advanced techniques to visualize these interactions in real-time, the study aims to uncover how cancer cells respond to treatments like osimertinib and how they develop resistance. The researchers will employ a novel method called rapid multiplexed protein interaction (RapMPI) to analyze both drug-sensitive and resistant cell lines, providing insights into the underlying mechanisms of treatment efficacy and resistance. This could lead to more effective therapies for patients facing challenges with current treatments.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for lung cancer patients, particularly those who have developed resistance to existing therapies.
How similar studies have gone: Other research has shown success in using similar approaches to study protein interactions in cancer, indicating a promising avenue for further exploration.
Where this research is happening
-
Georgia Institute of Technology
Atlanta, United States Active
Researchers
- Principal investigator: Coskun, Ahmet F. — Georgia Institute of Technology
- Study coordinator: Coskun, Ahmet F.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.