Investigating protein interactions in Alzheimer's disease
Analysis of protein interactions in neurodegenerative disease
['FUNDING_R01'] · SCRIPPS RESEARCH INSTITUTE, THE · NIH-11080229
This study is looking at how proteins interact in the brains of people with Late Onset Alzheimer's Disease to find new ways to develop better treatments, since current options aren't working well.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SCRIPPS RESEARCH INSTITUTE, THE (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11080229 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the protein interactions involved in Late Onset Alzheimer's Disease (LOAD), which is the most common form of age-related dementia. By using advanced mass spectrometry techniques, the study aims to analyze the biochemical characteristics of protein complexes within the endosomal-lysosomal network, which has been identified as a potential target for new drug development. The goal is to uncover how LOAD alters these protein interactions, potentially leading to new therapeutic strategies. This research is crucial as current treatments for LOAD are ineffective, and new drug targets are urgently needed.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who are at risk for or diagnosed with Late Onset Alzheimer's Disease.
Not a fit: Patients with early-onset Alzheimer's disease or other forms of dementia unrelated to LOAD may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new treatments that effectively target the underlying mechanisms of Alzheimer's disease.
How similar studies have performed: While the approach of analyzing protein-protein interactions is gaining traction, this specific focus on the endosomal-lysosomal network in LOAD is relatively novel and has not been extensively studied.
Where this research is happening
LA JOLLA, UNITED STATES
- SCRIPPS RESEARCH INSTITUTE, THE — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YATES III, JOHN R — SCRIPPS RESEARCH INSTITUTE, THE
- Study coordinator: YATES III, JOHN R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.