Investigating protein co-pathologies in Alzheimer's Disease and related dementias
Official title: Protein co-pathologies in Alzheimer's Disease and Related Dementias
Funded at University of Iowa · NIH-11040032 · Data updated 2026-11-12
This study is looking at how different types of protein clumps in the brain affect the progression of Alzheimer's and other dementias, aiming to better understand how these changes relate to memory and thinking problems in people who have passed away with these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $752,589 |
| NIH project number | 1R01AG091184-01 |
| Project ID | NIH-11040032 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Alzheimer's Disease or related dementias who have experienced cognitive decline.
✕Less likely to help
Patients with forms of dementia that do not involve protein co-pathologies may not benefit from this research.
What this research studies
This research focuses on understanding how different protein aggregates contribute to the progression of Alzheimer's Disease and related dementias. By examining the relationship between nerve pathology and brain pathology in individuals who have died with dementia, the study aims to identify how these co-pathologies affect cognitive function and clinical symptoms. The researchers will utilize advanced techniques, including unbiased stereology and high throughput screening, to analyze brainstem pathology and its impact on neurodegeneration. This comprehensive approach seeks to build a model that accounts for the complexities of dementia beyond the dominant pathology.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for Alzheimer's Disease and related dementias.
How similar studies have gone: Previous research has shown promising results in understanding the role of protein aggregates in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Iowa
Iowa City, United States Active
Researchers
- Principal investigator: Aldridge, Georgina — University of Iowa
- Study coordinator: Aldridge, Georgina
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.