Investigating protein changes in cancer cells at a single cell level
Official title: 3D Proteomics at Single Cell Resolution with Covalent Protein Painting (CPP)
Funded at Scripps Research Institute, the · NIH-10917675 · Data updated 2026-11-12
This study is looking at how proteins in cancer cells change and interact, which can help cancer grow, and it's for anyone interested in better ways to detect and treat cancer by understanding these differences in individual cancer cells.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | August 14, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $240,092 |
| NIH project number | 1R33CA272339-01A1 |
| Project ID | NIH-10917675 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with various types of cancer who are willing to provide tumor samples for analysis.
✕Less likely to help
Patients with non-cancerous conditions or those who do not have tumor samples available may not benefit from this research.
What this research studies
This research focuses on understanding how proteins in cancer cells change their structure and interactions, which can drive cancer progression. By using a novel technique called Covalent Protein Painting, the study aims to analyze protein conformations in individual cancer cells. This approach allows researchers to identify differences in protein behavior even among cells with the same genetic makeup, providing insights into tumor heterogeneity. The findings could lead to improved cancer detection and treatment strategies.
Why it matters
Potential benefit: If successful, this research could enhance the understanding of cancer biology and lead to more effective cancer therapies.
How similar studies have gone: Other research has shown promise in using advanced protein analysis techniques to understand cancer biology, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Scripps Research Institute, the
La Jolla, United States Active
Researchers
- Principal investigator: Yates Iii, John R — Scripps Research Institute, the
- Study coordinator: Yates Iii, John R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.