Investigating protein changes in Alzheimer's disease and related dementias
Official title: Proteogenomics of Splicing Proteinopathies in Neurodegeneration
Funded at St. Jude Children's Research Hospital · NIH-11112173 · Data updated 2026-11-12
This study is looking at how certain proteins in the brain might play a role in Alzheimer's disease, with the hope of finding new ways to treat the condition and help those affected by it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project start | June 1, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $913,225 |
| NIH project number | 1R01AG092468-01 |
| Project ID | NIH-11112173 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or related dementias.
✕Less likely to help
Patients with other forms of dementia not related to Alzheimer's disease may not receive benefit from this research.
What this research studies
This research focuses on understanding the role of protein aggregates in Alzheimer's disease (AD) and related dementias. By analyzing brain samples and using mouse models, the study aims to identify specific proteins involved in the disease process, particularly those related to RNA splicing. The researchers will explore how these proteins contribute to neurodegeneration and aim to uncover potential therapeutic targets. Patients may benefit from insights that could lead to new treatment strategies for AD.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective treatments for Alzheimer's disease and related dementias.
How similar studies have gone: Previous research has shown promise in understanding proteinopathies in neurodegeneration, suggesting that this approach could yield valuable insights.
Where this research is happening
-
St. Jude Children's Research Hospital
Memphis, United States Active
Researchers
- Principal investigator: Peng, Junmin — St. Jude Children's Research Hospital
- Study coordinator: Peng, Junmin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.