Investigating protein changes in Alzheimer's disease and related dementias
Proteogenomics of Splicing Proteinopathies in Neurodegeneration
This study is looking at how certain proteins in the brain might play a role in Alzheimer's disease, with the hope of finding new ways to treat the condition and help those affected by it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-11112173 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of protein aggregates in Alzheimer's disease (AD) and related dementias. By analyzing brain samples and using mouse models, the study aims to identify specific proteins involved in the disease process, particularly those related to RNA splicing. The researchers will explore how these proteins contribute to neurodegeneration and aim to uncover potential therapeutic targets. Patients may benefit from insights that could lead to new treatment strategies for AD.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or related dementias.
Not a fit: Patients with other forms of dementia not related to Alzheimer's disease may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective treatments for Alzheimer's disease and related dementias.
How similar studies have performed: Previous research has shown promise in understanding proteinopathies in neurodegeneration, suggesting that this approach could yield valuable insights.
Where this research is happening
Memphis, United States
- St. Jude Children's Research Hospital — Memphis, United States (Active)
Researchers
- Principal investigator: Peng, Junmin — St. Jude Children's Research Hospital
- Study coordinator: Peng, Junmin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.