Investigating protein changes in Alzheimer's disease
Cell Specific Perturbations of the Proteome in Alzheimer's Disease
This study is looking at how changes in brain proteins might play a role in Alzheimer's disease, especially in older adults, to help us understand why memory and thinking can decline as we age and find new ways to help.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10904863 on NIH RePORTER |
What this research studies
This research focuses on understanding how specific changes in proteins contribute to Alzheimer's disease, particularly in older adults. By examining the proteome, or the entire set of proteins produced in the brain, the study aims to uncover the mechanisms behind cognitive decline associated with aging and neurodegeneration. The approach involves analyzing protein dynamics, which are crucial for understanding how synaptic function and connectivity are affected in Alzheimer's. This could lead to insights into the early stages of the disease and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who are experiencing cognitive decline or have been diagnosed with Alzheimer's disease.
Not a fit: Patients under the age of 65 or those with cognitive decline due to causes other than Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease, improving cognitive health in older adults.
How similar studies have performed: Previous research has shown promising results in understanding protein dynamics in neurodegenerative diseases, indicating that this approach could yield valuable insights.
Where this research is happening
La Jolla, United States
- Scripps Research Institute, the — La Jolla, United States (Active)
Researchers
- Principal investigator: Yates Iii, John R — Scripps Research Institute, the
- Study coordinator: Yates Iii, John R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.