Investigating protein aggregation in neurodegenerative diseases like Alzheimer's and Parkinson's
Official title: BLR&D Research Career Scientist Award
Funded at Central Arkansas Veterans Hlthcare Sys · NIH-10946714 · Data updated 2026-11-12
This study is looking at how clumps of proteins might play a role in diseases like Alzheimer's and Parkinson's, and it's testing some new drugs that could help stop these clumps from forming, with the hope of finding better treatments for people affected by these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Central Arkansas Veterans Hlthcare Sys NIH-funded |
| Lab location | 1 site (North Little Rock, United States) |
| Project start | October 1, 2019 |
| Project end | September 30, 2026 |
| Funding year | 2025 |
| NIH project number | 5IK6BX004851-06 |
| Project ID | NIH-10946714 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's Disease or other age-related neurodegenerative disorders.
✕Less likely to help
Patients with neurodegenerative diseases not related to protein aggregation may not benefit from this research.
What this research studies
This research focuses on understanding how protein aggregates contribute to neurodegenerative diseases such as Alzheimer's and Parkinson's. By isolating and analyzing these aggregates from various models, including human cell cultures, the team aims to identify common proteins involved in these conditions. They are also screening drugs that may disrupt the formation of these aggregates, with some promising candidates already showing potential to reverse aggregation in animal models. The ultimate goal is to develop new drugs that can effectively target and treat these age-related diseases.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or reverse the progression of neurodegenerative diseases.
How similar studies have gone: Previous research has shown success in targeting protein aggregation in neurodegenerative diseases, indicating a promising avenue for treatment development.
Where this research is happening
-
Central Arkansas Veterans Hlthcare Sys
North Little Rock, United States Active
Researchers
- Principal investigator: Shmookler Reis, Robert Joseph — Central Arkansas Veterans Hlthcare Sys
- Study coordinator: Shmookler Reis, Robert Joseph
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.