Investigating pre-leukemic stem cells in acute myeloid leukemia
Official title: Pre-Leukemic Hematopoietic Stem Cells in Human AML
Funded at Stanford University · NIH-11025910 · Data updated 2026-11-12
This study is looking at how certain early blood cells might play a role in the development of acute myeloid leukemia (AML), and it aims to help patients by finding out more about their specific disease to tailor treatments just for them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $487,973 |
| NIH project number | 1R01CA296375-01 |
| Project ID | NIH-11025910 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults diagnosed with acute myeloid leukemia, particularly those over the age of 65.
✕Less likely to help
Patients with other types of leukemia or those without a diagnosis of acute myeloid leukemia may not benefit from this research.
What this research studies
This research focuses on understanding the role of pre-leukemic hematopoietic stem cells (HSCs) in acute myeloid leukemia (AML), a serious blood cancer. By analyzing genetic mutations in these stem cells, the study aims to identify how they contribute to the development and progression of AML. Patients may benefit from insights gained about their own disease, as the research seeks to stratify patients based on the presence of these pre-leukemic cells, potentially guiding more personalized treatment approaches. The methodology includes genomic studies and whole genome sequencing to track mutations and their impact on patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to improved survival rates and treatment strategies for patients with acute myeloid leukemia.
How similar studies have gone: Previous research has shown promising results in understanding the genetic basis of leukemia, indicating that this approach may yield valuable insights.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Majeti, Ravindra — Stanford University
- Study coordinator: Majeti, Ravindra
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.