Investigating platelet transfusion strategies in children on ECMO
ECmo hemoSTAtic Transfusions In Children (ECSTATIC)
This study is looking at kids who need special heart and lung support and might have low platelet counts, to see if giving them more or fewer platelet transfusions helps prevent serious bleeding or clots during their treatment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10913401 on NIH RePORTER |
What this research studies
This research focuses on children aged 0-18 who are supported by extracorporeal membrane oxygenation (ECMO) and are at risk of bleeding due to low platelet counts. The study will compare two different strategies for platelet transfusions: a liberal approach that aims for a higher platelet count and a restrictive approach that aims for a lower count. Children will be monitored for severe bleeding or thrombosis during their treatment. The goal is to provide evidence-based guidelines for clinicians to improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-18 who are currently receiving ECMO support and are not experiencing bleeding.
Not a fit: Patients who are already experiencing severe bleeding or those outside the age range of 0-18 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective platelet transfusion practices for critically ill children on ECMO.
How similar studies have performed: Previous observational studies have indicated risks associated with platelet transfusions in similar patient populations, highlighting the need for this novel approach.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Karam, Oliver L — Yale University
- Study coordinator: Karam, Oliver L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.