Investigating placental defects linked to early-onset preeclampsia using stem cells
Official title: Stem Cell-based Modeling of Placental Defects associated with Early-Onset Preeclampsia
Funded at University of California, San Diego · NIH-11122185 · Data updated 2026-11-12
This study is looking at how problems with the placenta might cause early-onset preeclampsia, a serious pregnancy condition, and aims to find better ways to diagnose and treat it by using a special stem cell model to understand what goes wrong in the placenta.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | July 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $595,911 |
| NIH project number | 5R01HD114720-02 |
| Project ID | NIH-11122185 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are pregnant individuals experiencing early-onset preeclampsia or those at risk for developing this condition.
✕Less likely to help
Patients who are not pregnant or those who have not experienced preeclampsia may not benefit from this research.
What this research studies
This research focuses on understanding the placental defects associated with early-onset preeclampsia, a serious pregnancy condition. By utilizing a novel stem cell-based modeling system, the researchers aim to explore how abnormal trophoblast differentiation occurs in the placenta of affected pregnancies. The study will involve detailed molecular characterization of the placenta and the role of mesenchymal stem/stromal cells in this process. Patients may benefit from insights that could lead to improved diagnostics and treatments for preeclampsia.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of preeclampsia, potentially improving outcomes for mothers and babies.
How similar studies have gone: While the approach of using stem cells to model placental defects is innovative, similar studies have shown promise in understanding other pregnancy-related conditions.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Horii, Mariko — University of California, San Diego
- Study coordinator: Horii, Mariko
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.