Investigating PGRMC proteins' role in fertility and health.
Official title: PGRMC Proteins as Markers of Fertility and Overall Health Status
Funded at University of Wyoming · NIH-10729068 · Data updated 2026-11-12
This study is looking at how certain proteins might affect women's fertility and health as they age, using mice to learn more about their role in reproductive health and heart disease, with the hope of finding helpful signs for women’s health.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wyoming NIH-funded |
| Lab location | 1 site (Laramie, United States) |
| Project start | September 15, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $397,375 |
| NIH project number | 1R21HD112788-01 |
| Project ID | NIH-10729068 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women experiencing fertility challenges or those with conditions like premature ovarian insufficiency.
✕Less likely to help
Patients who are male or those without fertility concerns may not receive any benefit from this research.
What this research studies
This research explores how PGRMC proteins are linked to female fertility and overall health, particularly in relation to ovarian aging and cardiovascular disease. The study involves genetic manipulation in mice to understand the functions of PGRMC1 and PGRMC2 proteins, which are believed to influence reproductive health and aging. By examining the effects of these proteins on fertility and health outcomes, the research aims to uncover potential biomarkers for assessing reproductive health in women.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of fertility issues and associated health risks in women.
How similar studies have gone: Previous research has shown promising results in understanding the role of hormonal receptors in fertility, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Wyoming
Laramie, United States Active
Researchers
- Principal investigator: Pru, James K — University of Wyoming
- Study coordinator: Pru, James K
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.