Investigating PASK as a target for treating ALS and frontotemporal dementia
PASK-regulated genes and proteins as therapeutic targets for ALS and FTD
This study is looking at how a protein called PASK affects diseases like ALS and frontotemporal dementia, with the hope of finding new ways to treat these conditions and help patients feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-10872746 on NIH RePORTER |
What this research studies
This research focuses on understanding how the PASK protein influences neurodegenerative diseases like ALS and frontotemporal dementia (FTD). By studying the relationship between PASK and other proteins involved in cellular processes, the researchers aim to identify new therapeutic targets. The approach involves using genetic techniques and specific inhibitors to manipulate PASK levels in cell cultures and animal models, which may lead to improved cellular function and reduced disease symptoms. Patients may benefit from potential new treatments that target the underlying mechanisms of these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with ALS or frontotemporal dementia.
Not a fit: Patients with other forms of dementia unrelated to ALS or FTD may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that slow down or halt the progression of ALS and FTD.
How similar studies have performed: Previous research has shown promise in targeting similar pathways in neurodegenerative diseases, suggesting potential for success in this approach.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Scoles, Daniel R — University of Utah
- Study coordinator: Scoles, Daniel R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.