Investigating pancreatic cancer treatments using mouse models
Official title: Core 3: Mouse Models Core (MM Core)
Funded at Salk Institute for Biological Studies · NIH-10883584 · Data updated 2026-11-12
This study is using mice to learn more about pancreatic cancer and test new treatments, which could help improve options for patients like you in the future.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Salk Institute for Biological Studies NIH-funded |
| Lab location | 1 site (La Jolla, UNITED STATES) |
| Project start | July 6, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $472,258 |
| NIH project number | 5P01CA265762-02 |
| Project ID | NIH-10883584 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with pancreatic cancer who may benefit from novel treatment strategies.
✕Less likely to help
Patients with non-cancerous conditions or those not diagnosed with pancreatic cancer may not receive any benefit from this research.
What this research studies
This research focuses on developing and utilizing mouse models to study pancreatic cancer and test new therapeutic strategies. The Mouse Models Core will provide essential services, including orthotopic transplantation of mouse and human pancreatic cancer organoids, to analyze treatment responses and resistance mechanisms. By employing standardized procedures and imaging protocols, the research aims to ensure reliable and reproducible results across various experimental trials. Patients may benefit from insights gained through these preclinical studies, which could lead to improved treatment options for pancreatic cancer.
Why it matters
Potential benefit: If successful, this research could lead to more effective therapies for pancreatic cancer, improving patient outcomes.
How similar studies have gone: Previous research using mouse models for cancer treatment has shown promising results, indicating that this approach is both established and valuable.
Where this research is happening
-
Salk Institute for Biological Studies
La Jolla, United States Active
Researchers
- Principal investigator: Wahl, Geoffrey Myles — Salk Institute for Biological Studies
- Study coordinator: Wahl, Geoffrey Myles
Related research
Other NIH-funded projects on the same topics.
-
InteroCANCEption: How tumors and the brain talk to each other
A scientist team at a top research center is studying how cancer communicates with the nervous system to influence tumor growth, immunity, and symptoms, using mouse models and brain/nerve mapping.
-
Studying Brain Protein Turnover in Aging and Alzheimer’s with New Tagging Tools
A scientist at a major research center is testing a new method to track how brain proteins are built and cleared as people age and in Alzheimer’s disease, with the goal of understanding why this process goes wrong.
-
Tracking how cancer cells adapt when autophagy is blocked
Scientists are studying how cancer cells change and survive when a key recycling process called autophagy is blocked, with the goal of finding new ways to prevent resistance to therapy.
-
Understanding how the brain attaches meaning to experiences and emotions
This NIH grant supports research to map how brain circuits and signals assign positive or negative meaning to things, and how this changes with life events, with the aim of improving mental health treatments.
-
Molecular control of ROR-gamma-t in the chromatin landscape
A study to understand how the immune-regulating protein ROR-gamma-t works inside the DNA environment to influence immune responses and autoimmune diseases.
-
How chromatin loops are built and kept steady inside living cells
This project studies how the DNA packaging proteins CTCF and Cohesin shape 3D genome structure inside living cells and how loops are formed and maintained.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.