Investigating pain pathways in knee osteoarthritis
Novel models to study dorsal root ganglion neurons in knee osteoarthritis pain
['FUNDING_CAREER'] · STANFORD UNIVERSITY · NIH-10783393
This study is looking at how certain nerve cells in the knee might be causing pain for people with osteoarthritis, and it hopes to find new ways to help relieve that pain without messing with how the knee works.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-10783393 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how specific nerve cells, known as dorsal root ganglion neurons, contribute to pain in knee osteoarthritis. By studying these neurons, the research aims to identify targeted therapies that can alleviate pain without affecting other important functions, such as knee stability. The approach involves advanced techniques to precisely manipulate and observe these neurons in a controlled environment, which could lead to new pain management strategies for patients suffering from knee osteoarthritis.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 45 who are experiencing chronic pain due to knee osteoarthritis.
Not a fit: Patients with knee osteoarthritis who do not experience significant pain may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer pain relief options for patients with knee osteoarthritis.
How similar studies have performed: Other research has shown promise in targeting specific nerve pathways for pain relief, indicating that this approach could be effective.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BREWER, CHELSIE L — STANFORD UNIVERSITY
- Study coordinator: BREWER, CHELSIE L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: degenerative joint disease