Investigating pain mechanisms in chronic inflammatory conditions
Official title: NEURAXIAL AAVS TARGETING DRG CHANNELS INVOLVED IN CHRONIC POST INFLAMMATORY PAIN
Funded at University of California, San Diego · NIH-11004639 · Data updated 2026-11-12
This study is looking into why some people still feel pain after their inflammation goes away, especially those with arthritis, and it hopes to find new ways to help relieve that ongoing pain.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $561,031 |
| NIH project number | 5R01NS131560-02 |
| Project ID | NIH-11004639 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from chronic pain related to inflammatory diseases such as arthritis.
✕Less likely to help
Patients with acute pain not related to chronic inflammatory conditions may not benefit from this research.
What this research studies
This research focuses on understanding the mechanisms behind chronic pain that persists after inflammation has resolved, particularly in conditions like arthritis. It uses a preclinical model to explore how changes in nerve biology and channel expression in the dorsal root ganglia (DRG) contribute to ongoing pain. By employing advanced techniques like CRISPR, the study aims to identify potential therapeutic targets that could alleviate this pain. Patients may benefit from insights that lead to new treatments for chronic pain associated with inflammatory diseases.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively manage chronic pain in patients with inflammatory conditions.
How similar studies have gone: Previous research has shown promise in targeting pain mechanisms in similar inflammatory conditions, suggesting potential for success in this approach.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Yaksh, Tony L. — University of California, San Diego
- Study coordinator: Yaksh, Tony L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.