Investigating pain mechanisms and treatments in HIV patients
Chronic Widespread Pain in HIV: Novel Mechanisms and Therapeutics
This study is looking at why some people with HIV experience ongoing pain all over their bodies, and it hopes to find new ways to help relieve that pain and improve their daily lives.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida International University NIH-funded |
| Lab location | 1 site (Miami, United States) |
| Project ID | NIH-11146595 on NIH RePORTER |
What this research studies
This research focuses on understanding chronic widespread pain (CWP) in individuals living with HIV, a condition that affects a significant number of patients despite effective viral treatment. The study aims to identify the biological mechanisms behind CWP, particularly the role of cell-free heme and its impact on pain-related opioid levels in the body. By exploring these mechanisms, the research seeks to develop new therapeutic strategies that could alleviate pain and improve the quality of life for HIV patients. The approach includes both pharmacological and non-pharmacological methods to address this complex issue.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who experience chronic widespread pain.
Not a fit: Patients without HIV or those who do not experience chronic pain may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively reduce chronic pain in HIV patients, enhancing their overall quality of life.
How similar studies have performed: Previous research has shown that understanding the biological mechanisms of pain can lead to effective treatments, suggesting potential success for this novel approach.
Where this research is happening
Miami, United States
- Florida International University — Miami, United States (Active)
Researchers
- Principal investigator: Aggarwal, Saurabh — Florida International University
- Study coordinator: Aggarwal, Saurabh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.