Investigating pain management in patients with major burn injuries
Major Burn Injury and its Effects on Acute and Superimposed Surgical Pain
This study is looking at the severe pain that people with major burn injuries feel, especially during surgeries like skin grafts, and it aims to find new ways to relieve that pain without using opioids, by exploring how the gut and immune system might help.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10684657 on NIH RePORTER |
What this research studies
This research focuses on understanding the intense pain experienced by patients with major burn injuries, particularly how this pain is exacerbated during surgical procedures like skin grafts. The study aims to explore the underlying biological mechanisms of this pain and to identify new non-opioid treatments that could provide better pain relief. By examining the role of the gut microbiome and immune responses, the researchers hope to develop therapies that can effectively reduce pain and improve recovery outcomes for burn patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 21 and older who have sustained major burn injuries and are experiencing significant pain.
Not a fit: Patients with minor burns or those who do not experience significant pain may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective pain management strategies for patients suffering from major burn injuries.
How similar studies have performed: Previous research has shown promise in using non-opioid therapies and understanding the gut-brain connection in pain management, suggesting that this approach may yield beneficial results.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Martyn, Jeevendra — Massachusetts General Hospital
- Study coordinator: Martyn, Jeevendra
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.