Investigating pain and abnormal bone growth after injuries
ACVR1 sensory neuron-specific signaling in neuropathic pain and injury-induced heterotopic ossification
This study is looking at how certain nerve cells might cause pain and unusual bone growth after injuries or surgeries, especially in people with a rare condition called Fibrodysplasia Ossificans Progressiva (FOP), to find better ways to help manage these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10914940 on NIH RePORTER |
What this research studies
This research focuses on understanding the mechanisms behind debilitating pain and abnormal bone growth, known as heterotopic ossification (HO), that can occur after injuries or surgeries. By studying sensory neurons and their signaling pathways, particularly in patients with a genetic condition called Fibrodysplasia Ossificans Progressiva (FOP), the research aims to uncover how these neurons contribute to pain and bone formation. The approach involves using patient-derived stem cells to create sensory neurons in the lab, allowing researchers to explore their behavior and interactions in detail. This could lead to new insights into treating pain and HO effectively.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults with a history of traumatic injuries or orthopedic surgeries, particularly those experiencing chronic pain or abnormal bone growth.
Not a fit: Patients without a history of musculoskeletal injuries or those not experiencing chronic pain may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for managing pain and preventing abnormal bone growth in patients with musculoskeletal injuries.
How similar studies have performed: Previous research on genetic conditions like FOP has provided valuable insights, suggesting that this approach could yield significant findings in understanding pain and bone growth.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Yu, Xiaobing — University of California, San Francisco
- Study coordinator: Yu, Xiaobing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.