Investigating ovarian cancer organoids and biomarkers for treatment
Organoid, Mouse Model, and Biomarker
This study is looking at ways to grow tiny versions of ovarian cancer tumors from patient samples to test how well different drug combinations work, helping to find personalized treatments that fit each person's unique cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10895319 on NIH RePORTER |
What this research studies
This research focuses on developing organoid cultures derived from ovarian cancer tissues, which closely mimic the original tumors. By utilizing these organoids, researchers aim to evaluate the effectiveness of various drug combinations and assess biomarkers related to DNA repair and apoptosis. The project includes collecting ovarian cancer tissue samples and using patient-derived xenograft (PDX) models to study treatment responses in a controlled environment. This approach allows for personalized treatment strategies based on individual tumor characteristics.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with ovarian cancer who are willing to provide tissue samples for organoid development.
Not a fit: Patients with non-ovarian cancers or those who are not eligible for tissue collection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment options for ovarian cancer patients.
How similar studies have performed: Previous research has shown promise in using organoid models for cancer treatment evaluation, indicating that this approach could be effective.
Where this research is happening
Boston, United States
- Dana-Farber Cancer Inst — Boston, United States (Active)
Researchers
- Principal investigator: D'andrea, Alan D. — Dana-Farber Cancer Inst
- Study coordinator: D'andrea, Alan D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.